Tretinoin Microsphere Gel
A type of topical retinoid known as Tretinoin Microsphere Gel can treat a wide range of skin conditions. It increases the thickness of the skin's surface layer, making it one of the newest members of the retinoid family. However, there are some negative effects as well.
Safety analysis
Acne vulgaris can be treated with the topical treatment Tretinoin Microsphere Gel. It comes in two concentrations and contains tretinoin. 0.04 percent is the lowest concentration. There are also 0.1% and 0.02% formulations.
In a phase three study, clindamycin 1% gel monotherapies and tretinoin microsphere 0.04% monotherapies were compared. The results demonstrated that the combination treatment significantly reduced total lesions. Additionally, the combination resulted in less inflammatory as well as noninflammatory lesions. However, there was no discernible difference between the tretinoin gel and the tretinoinoids in the outcomes.
Safety evaluations for adverse events were part of the topical tretinoin formulations' safety analysis. Peeling, dryness, and burning were among the cutaneous irritancy reactions experienced by 14% of subjects. Urticaria was experienced by one patient.
Children, adolescents, and people with sensitization reactions should not take Retin-A Micro. This is because rat teratogenicity studies have yielded equivocal results and excessive oral administration of the medication may result in side effects comparable to those of vitamin A. Female mice and rabbits were not found to be teratogenic.
Pharmacokinetics
Tretinoin, an endogenous vitamin A metabolite, is an effective acne vulgaris topical treatment. Tretinoin is thought to regulate epidermal cell proliferation, differentiation, and granulation, though the exact mechanism of action is unknown. It reduces the formation of cornified cells in addition to its anti-acne activity.
After being applied topically, human studies have shown that tretinoin is absorbed in a rate of 1-31% on average. However, this rate of absorption is not constant and can be affected by food and the frequency with which skin treatments are applied. This is a reflection of how it interacts with spices, foods, and astringents. As a result, eczema caused by autoimmune diseases, AIDS-related Kaposi sarcoma, or eczema caused by eczema should not be treated with tretinoin.
Alcohol, irritating excipients, and high concentrations of the active drug were all present in the initial formulations of tretinoin. In bright light, these formulations frequently became unstable. Polymeric microspheres that resemble sponges were created by researchers to address this issue.
Photostability has been improved by tretinoin microspheres. Additionally, it has been demonstrated that they are less susceptible to bacterial contamination. Additionally, it is said that they lessen oiliness.