Cognitive Training Institute

University of Minnesota Medical Center, Fairview-Riverside

We plan to have a work product (1-2 papers) come out of this meeting.

Please also forward this message to any other colleagues or trainees who are doing work in this area. We can still accommodate additional attendees.

Campus Club of University of Minnesota

Coffman Memorial Union, 4th Floor

300 Washington Ave SE

Minneapolis, MN 55455

TUESDAY, MAY 1 | 6:00 PM

• 8:30-9:00a -- Registration and Breakfast
  
• 9:00a-12:30p -- Morning Keynotes
• 12:30-1:00p -- Lunch Break
• 1:00-3:00p -- Afternoon Roudtable Discussions
• 3:00-3:30p -- Afternoon Break
• 3:30-5:00p -- Large Group Discussion and Work Product Action Items

The Agenda for each Discussion Group will be:

1. Flash Talks
2. Discuss Questions (see below): identify those questions where there is a consensus or you feel there is sufficient evidence to provide a meaningful answer vs. those questions which require further investigation
3. Bring your input to the large group

1. How to best generate animal models relevant to human cognition?

• Role of rodent vs. primate studies
• Similarity and differences of brain regions/behaviors across species

2. What gaps in knowledge can be only addressed using animal models?

• Impact of specific genetic, molecular, or cellular phenotypes on cognition
• Invasive tools/causal manipulations

3. Can animal/computational models inform development of novel neuro-cognitive therapies?

• Better understanding of how neuromodulatory/cognitive remediation strategies induce neuroplasticity
• Using computational modeling of large-scale human data (behavior/physiology/functional outcomes) to better understand connections.

4. How to best design/collaborate on cross-species studies and/or integrate computational models within a human RCT?

1. How do we incorporate best practices for the next generation of cognitive training studies in humans?

• Can we agree on the Consensus Recommendations from the Bavelier/Green workshop?
• Should there be a set of Common Data Elements we try to use across studies?

2. How do we define training targets and demonstrate target engagement?

• Behavioral targets?
• Neurophysiologic targets?
• Use of EEG/imaging biomarkers?

3. What kinds of study designs can be used to develop personalized interventions?

4. What are the next steps to support evidence-based clinical dissemination?

1. What evidence exists for the efficacy of cognitive control training in psychiatric disorders?

• Both behavioral and neural evidence
• Depression/Anxiety/Bipolar/PTSD
• Schizophrenia
• Autism/ADHD

2. How do we combine cognitive control training with neuromodulation approaches?

• Non-invasive brain stimulation (TMS, tDCS)
• Evidence from clinical and non-clinical populations

3. Which parameters of cognitive/attentional control training are most critical for driving positive outcomes?

• Sustained attention
• Motivation/reward

4. Executive dysfunction across various conditions - do we use the same approach?

• PFC injury (e.g., concussion/TBI/ABI) vs. mental illness
• Neurodevelopmental disorders (e.g., ADHD, ASD) vs. 'adult' conditions